PF3D7_0601600

Genome location: Pf3D7_06_v3:68,698..70,201(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005680	anaphase-promoting complex
Component	GO:0005737	cytoplasm
Process	GO:0031145	anaphase-promoting complex-dependent catabolic process
Process	GO:0051301	cell division
Process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition
Process	GO:0016567	protein ubiquitination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0601600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.192 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1129800)

Relative Growth Rate: 1.07 ± 0.14
Confidence: 5.33

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1129800)

Modification: Tagged | RMgm-959

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSL8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116571

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 104

Non-coding: 77 | Synonymous: 24 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 286 | Molecular Weight (kDa): 33.594

UniProt ID(s): C6KSL8

PDB ID(s): None

Isoelectric Point: 7.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	PF13181	Tetratricopeptide repeat
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily