PF3D7_0602000

Genome location: Pf3D7_06_v3:81,532..88,869(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.07	0.96
Trophozoite	expressed	0.19	0.88
Schizont	expressed	0.12	0.92
Gametocyte	expressed	0.89	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0602000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.627 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0100800)

Relative Growth Rate: 1.00 ± 0.11
Confidence: 5.74

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0100800)

Modification: Disrupted | RMgm-1603

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSM0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130927

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	65	25	73
disruptive	43	152	73	204
missense	26	108	58	167

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	124	64	101
disruptive	79	350	165	399
missense	41	257	133	272

PlasmoDB Total SNPs: 302

Non-coding: 178 | Synonymous: 85 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1437 | Molecular Weight (kDa): 165.399

UniProt ID(s): C6KSM0

PDB ID(s): None

Isoelectric Point: 7.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104