PF3D7_0602200

Genome location: Pf3D7_06_v3:97,494..99,410(+)

Genome classification: Core

Function and Localization

Product Description: MYND-type zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.26	0.87
Trophozoite	no data	0.58	0.68
Schizont	no data	0.09	0.94
Gametocyte	no data	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0602200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.003 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSM2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110519

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	13	10	19
disruptive	5	17	7	25
missense	5	17	7	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	33	8	16
disruptive	7	35	20	51
missense	6	30	18	36

PlasmoDB Total SNPs: 86

Non-coding: 71 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 252 | Molecular Weight (kDa): 29.441

UniProt ID(s): C6KSM2

PDB ID(s): None

Isoelectric Point: 5.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002893	Zinc finger, MYND-type
PFam	PF01753	Zinc finger, MYND-type
Superfamily	SSF144232	N/A