PF3D7_0602300 (PALM)

Genome location: Pf3D7_06_v3:99,781..100,725(+)

Genome classification: Core

Function and Localization

Product Description: liver merozoite formation protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.02	0.98
Schizont	no data	0.01	1.00
Gametocyte	no data	0.07	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0602300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.795 | MFS: -3.057 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0101100)

Relative Growth Rate: 1.00 ± 0.13
Confidence: 5.54

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0101100)

Modification: Disrupted | RMgm-4942

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSM3

"Best" AlphaFill ligand hit: SFG (sinefungin, Local RMSD=2.36) with 7DSU (Global RMSD=14.57)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533115

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	11	4	15
disruptive	6	18	18	49
missense	5	17	18	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	18	11	16
disruptive	11	53	22	88
missense	8	43	19	55

PlasmoDB Total SNPs: 10

Non-coding: 0 | Synonymous: 2 | Nonsynonymous: 7 | Stop Codon: 1

Protein Information

Protein Length: 314 | Molecular Weight (kDa): 38.237

UniProt ID(s): C6KSM3

PDB ID(s): None

Isoelectric Point: 8.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
21848587	Inactivation of a Plasmodium apicoplast protein attenuates formation of livermerozoites.	Haussig JM, Matuschewski K, Kooij TW	10.1111/j.1365-2958.2011.07787.x