Product Description: SAC3 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0070390 | transcription export complex 2 |
| Process | GO:0006406 | mRNA export from nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.62 | 0.71 |
| Trophozoite | possibly expressed | 0.40 | 0.76 |
| Schizont | not expressed | 0.16 | 0.90 |
| Gametocyte | not expressed | 0.50 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0602600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.16 | MFS: -2.899 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSM6
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=8.23) with 2OK7 (Global RMSD=18.38)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101802
Most Similar Human Ortholog: H7BZP5
TM-align score: 0.40 | RMSD: 4.23
Seq Identity: 0.01 | Length: 68 / 1297
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000167615 | leukocyte receptor cluster member 8 |
| ENSG00000274305 | leukocyte receptor cluster member 8 |
| ENSG00000276458 | leukocyte receptor cluster member 8 |
| ENSG00000276681 | leukocyte receptor cluster member 8 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 57 | 32 | 68 |
| disruptive | 44 | 147 | 76 | 202 |
| missense | 31 | 127 | 72 | 166 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 119 | 45 | 99 |
| disruptive | 82 | 346 | 160 | 405 |
| missense | 56 | 266 | 120 | 243 |
PlasmoDB Total SNPs: 226
Non-coding: 130 | Synonymous: 69 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 1297 | Molecular Weight (kDa): 153.719
UniProt ID(s): C6KSM6
PDB ID(s): None
Isoelectric Point: 8.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005062 | SAC3/GANP/THP3 |
| PFam | PF03399 | SAC3/GANP/THP3 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |