PF3D7_0602900

Genome location: Pf3D7_06_v3:118,239..120,929(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.37	0.82
Trophozoite	possibly expressed	0.29	0.82
Schizont	expressed	0.61	0.64
Gametocyte	expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0602900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.752 | MFS: -2.983 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSM9

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=16.00) with 1DEJ (Global RMSD=29.16)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532638

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	22	11	21
disruptive	11	60	22	67
missense	8	53	22	59

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	39	16	28
disruptive	17	127	53	130
missense	11	113	42	78

PlasmoDB Total SNPs: 149

Non-coding: 112 | Synonymous: 24 | Nonsynonymous: 12 | Stop Codon: 1

Protein Information

Protein Length: 470 | Molecular Weight (kDa): 56.371

UniProt ID(s): C6KSM9

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A