About Gene List

PF3D7_0603000

Genome location: Pf3D7_06_v3:121,248..124,846(+)

Genome classification: Core

Function and Localization

Product Description: SDE2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.23 0.88
Trophozoite expressed 0.25 0.84
Schizont expressed 0.38 0.76
Gametocyte expressed 0.56 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0603000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.909 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532408

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 24 13 38
disruptive 25 61 39 86
missense 21 51 32 67

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 58 21 45
disruptive 51 150 74 161
missense 35 105 56 103

PlasmoDB Total SNPs: 252

Non-coding: 173 | Synonymous: 44 | Nonsynonymous: 35 | Stop Codon: 0

Protein Information

Protein Length: 592 | Molecular Weight (kDa): 69.666

UniProt ID(s): C6KSN0

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source Family ID Description
InterPro IPR024974 Sde2, N-terminal ubiquitin domain
PFam PF13019 Sde2, N-terminal ubiquitin domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108