About Gene List

PF3D7_0603100

Genome location: Pf3D7_06_v3:125,002..127,010(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite expressed 0.31 0.80
Schizont expressed 0.14 0.90
Gametocyte expressed 0.57 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0603100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.971 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533173

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 10 4 19
disruptive 16 46 26 66
missense 11 37 25 56

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 23 17 21
disruptive 21 96 46 108
missense 15 75 40 76

PlasmoDB Total SNPs: 129

Non-coding: 61 | Synonymous: 42 | Nonsynonymous: 24 | Stop Codon: 2

Protein Information

Protein Length: 452 | Molecular Weight (kDa): 53.576

UniProt ID(s): C6KSN1

PDB ID(s): None

Isoelectric Point: 6.64

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008374 SF-assemblin/beta-giardin
InterPro IPR035979 RNA-binding domain superfamily
PFam N/A N/A
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104