Product Description: mitochondrial chaperone BCS1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016887 | ATP hydrolysis activity |
| Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Process | GO:0065003 | protein-containing complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.45 | 0.73 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | expressed | 0.12 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0603200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.226 | MFS: -2.638 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0102000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSN2
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.13) with 2QZ4 (Global RMSD=8.79)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101424
Most Similar Human Ortholog: A0A2R8Y7T3
TM-align score: 0.78 | RMSD: 2.98
Seq Identity: 0.27 | Length: 150 / 471
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000074582 | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 26 | 15 | 23 |
| disruptive | 8 | 37 | 19 | 61 |
| missense | 8 | 35 | 19 | 46 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 48 | 18 | 32 |
| disruptive | 15 | 92 | 47 | 109 |
| missense | 11 | 74 | 33 | 63 |
PlasmoDB Total SNPs: 79
Non-coding: 58 | Synonymous: 12 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 471 | Molecular Weight (kDa): 54.6
UniProt ID(s): C6KSN2
PDB ID(s): None
Isoelectric Point: 9.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR003959 | ATPase, AAA-type, core |
| InterPro | IPR014851 | BCS1, N-terminal |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00004 | ATPase, AAA-type, core |
| PFam | PF08740 | BCS1, N-terminal |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 34274978 | Modelling of BCS1L-related human mitochondrial disease in Drosophilamelanogaster | Brischigliaro M, Frigo E, ..., Costa R | 10.1007/s00109-021-02110-1 |
| 36993815 | Bcs1, a novel target for fungicide | Zhan J, Xia D | 10.3389/fchem.2023.1146753 |