PF3D7_0603400 (TEX1)

Genome location: Pf3D7_06_v3:132,888..138,199(-)

Genome classification: Core

Function and Localization

Product Description: trophozoite exported protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Function	GO:0061630	ubiquitin protein ligase activity
Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.47	0.77
Trophozoite	possibly expressed	0.95	0.50
Schizont	not expressed	0.29	0.83
Gametocyte	not expressed	0.73	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0603400

Resistome Missense Mutations: I1063M

Resistome Compounds with Missense Mutations: MMV023949

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.087 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0102200)

Relative Growth Rate: 1.02 ± 0.19
Confidence: 4.75

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0102200)

Modification: Disrupted | RMgm-1611

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q6LFN2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532864

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	50	37	65
disruptive	50	146	80	187
missense	36	134	73	167

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	84	43	78
disruptive	89	273	136	215
missense	61	244	119	179

PlasmoDB Total SNPs: 183

Non-coding: 102 | Synonymous: 31 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1103 | Molecular Weight (kDa): 132.471

UniProt ID(s): Q6LFN2

PDB ID(s): None

Isoelectric Point: 5.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
PFam	PF13920	N/A
Superfamily	SSF57850	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23056243	Cell biological characterization of the malaria vaccine candidate trophozoiteexported protein 1.	Kulangara C, Luedin S, ..., Felger I	10.1371/journal.pone.0046112
33787496	Cryo-EM structure of the yeast TREX complex and coordination with the SR-likeprotein Gbp2	Xie Y, Clarke BP, ..., Ren Y	10.7554/eLife.65699
33191913	Structural insights into the nucleic acid remodeling mechanisms of the yeastTHO-Sub2 complex	Schuller SK, Schuller JM, ..., Conti E	10.7554/eLife.61467
29945169	The Candidate Blood-stage Malaria Vaccine P27A Induces a Robust Humoral Responsein a Fast Track to the Field Phase 1 Trial in Exposed and Nonexposed Volunteers	Steiner-Monard V, Kamaka K, ..., Jongo SA	10.1093/cid/ciy514
32210975	Epitope Mapping and Fine Specificity of Human T and B Cell Responses for NovelCandidate Blood-Stage Malaria Vaccine P27A	Geiger KM, Guignard D, ..., Audran R	10.3389/fimmu.2020.00412