Product Description: cation/H+ antiporter
SignalP Peptide: N/A
# Transmembrane Domains: 11
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008273 | calcium, potassium:sodium antiporter activity |
| Function | GO:0015369 | calcium:proton antiporter activity |
| Process | GO:0070588 | calcium ion transmembrane transport |
| Process | GO:0006816 | calcium ion transport |
| Process | GO:0006874 | cellular calcium ion homeostasis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.03 | 0.97 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0603500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.63 | MFS: -2.908 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0102300)
Modification: Tagged | RMgm-848
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSN3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 26 | 7 | 22 |
| disruptive | 0 | 12 | 4 | 27 |
| missense | 0 | 11 | 4 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 53 | 16 | 25 |
| disruptive | 2 | 30 | 18 | 58 |
| missense | 1 | 22 | 14 | 50 |
PlasmoDB Total SNPs: 68
Non-coding: 58 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 441 | Molecular Weight (kDa): 48.919
UniProt ID(s): C6KSN3
PDB ID(s): None
Isoelectric Point: 6.77
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004713 | Calcium/proton exchanger |
| InterPro | IPR004798 | Calcium/proton exchanger CAX |
| InterPro | IPR004837 | Sodium/calcium exchanger membrane region |
| PFam | PF01699 | Sodium/calcium exchanger membrane region |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20487273 | PfCHA is a mitochondrial divalent cation/H+ antiporter in Plasmodium falciparum. | Rotmann A, Sanchez C, ..., Lanzer M | 10.1111/j.1365-2958.2010.07187.x |
| 37786692 | A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Rangeof Human and Viral CaaX Sequences | Hildebrandt ER, Sarkar A, ..., Schmidt WK | 10.1101/2023.09.19.558494 |