PF3D7_0603600

Genome location: Pf3D7_06_v3:140,777..149,585(-)

Genome classification: Core

Function and Localization

Product Description: male development protein MD4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.12	0.95
Trophozoite	possibly expressed	0.30	0.85
Schizont	possibly expressed	0.14	0.92
Gametocyte	expressed	1.75	0.25

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0603600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.564 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0102400)

Relative Growth Rate: 0.98 ± 0.12
Confidence: 5.62

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0102400)

Modification: Tagged | RMgm-5375

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533716

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	24	124	64	130
disruptive	93	326	176	422
missense	71	292	161	371

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	223	96	159
disruptive	159	669	267	561
missense	119	576	223	421

PlasmoDB Total SNPs: 345

Non-coding: 144 | Synonymous: 114 | Nonsynonymous: 87 | Stop Codon: 0

Protein Information

Protein Length: 2368 | Molecular Weight (kDa): 280.498

UniProt ID(s): C6KSN4

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001606	ARID DNA-binding domain
InterPro	IPR036431	ARID DNA-binding domain superfamily
PFam	PF01388	ARID DNA-binding domain
Superfamily	SSF46774	ARID DNA-binding domain superfamily