About Gene List

PF3D7_0603800 (CEP76)

Genome location: Pf3D7_06_v3:152,505..160,682(-)

Genome classification: Core

Function and Localization

Product Description: NdP2 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0005813 centrosome
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.08 0.96
Trophozoite expressed 0.40 0.78
Schizont expressed 1.33 0.43
Gametocyte expressed 0.39 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0603800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.201 | MFS: -2.712 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0102600)

  • Relative Growth Rate: 0.04 ± 0.06
  • Confidence: 6.90

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126374

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 68 42 91
disruptive 37 115 87 195
missense 28 98 81 174

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 142 67 102
disruptive 67 253 138 321
missense 39 208 117 243

PlasmoDB Total SNPs: 390

Non-coding: 277 | Synonymous: 81 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 1826 | Molecular Weight (kDa): 219.258

UniProt ID(s): C6KSN6

PDB ID(s): None

Isoelectric Point: 6.83

Protein Domain Annotations:

Source Family ID Description
InterPro IPR038765 Papain-like cysteine peptidase superfamily
PFam N/A N/A
Superfamily SSF49562 Papain-like cysteine peptidase superfamily
Superfamily SSF54001

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33495622 An Alveolata secretory machinery adapted to parasite host cell invasion. Aquilini E, Cova MM, ..., Lebrun M 10.1038/s41564-020-00854-z