PF3D7_0603900

Genome location: Pf3D7_06_v3:160,825..162,616(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.05	0.97
Schizont	no data	0.08	0.95
Gametocyte	no data	0.71	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0603900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.638 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122808

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	18	8	19
disruptive	7	25	16	49
missense	7	25	15	47

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	32	15	18
disruptive	15	69	34	81
missense	9	58	31	63

PlasmoDB Total SNPs: 73

Non-coding: 54 | Synonymous: 8 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 375 | Molecular Weight (kDa): 45.172

UniProt ID(s): C6KSN7

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A