PF3D7_0604000

Genome location: Pf3D7_06_v3:163,582..170,363(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.25	0.86
Schizont	not expressed	0.08	0.95
Gametocyte	not expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0604000

Resistome Missense Mutations: N1614H

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.946 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN8

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=7.27) with 8CJD (Global RMSD=16.88)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532423

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	24	89	39	128
disruptive	78	292	178	366
missense	44	243	157	316

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	166	78	160
disruptive	153	619	249	517
missense	85	492	204	375

PlasmoDB Total SNPs: 270

Non-coding: 67 | Synonymous: 116 | Nonsynonymous: 87 | Stop Codon: 0

Protein Information

Protein Length: 2010 | Molecular Weight (kDa): 239.913

UniProt ID(s): C6KSN8

PDB ID(s): None

Isoelectric Point: 9.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A