About Gene List

PF3D7_0604100 (SIP2)

Genome location: Pf3D7_06_v3:170,776..178,985(-)

Genome classification: Core

Function and Localization

Product Description: AP2 domain transcription factor

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034399 nuclear periphery
Component GO:0005634 nucleus
Function GO:0043565 sequence-specific DNA binding
Function GO:0042162 telomeric DNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite not expressed 0.40 0.80
Schizont expressed 2.19 0.30
Gametocyte not expressed 0.25 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0604100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.576 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSN9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533519

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 129 57 124
disruptive 69 302 196 404
missense 45 264 175 349

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 42 232 104 133
disruptive 119 686 280 585
missense 75 591 253 415

PlasmoDB Total SNPs: 351

Non-coding: 209 | Synonymous: 81 | Nonsynonymous: 60 | Stop Codon: 1

Protein Information

Protein Length: 1979 | Molecular Weight (kDa): 229.626

UniProt ID(s): C6KSN9

PDB ID(s): 6SY0

Isoelectric Point: 6.07

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
20195509 A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosomeend biology. Flueck C, Bartfai R, ..., Voss TS 10.1371/journal.ppat.1000784
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
32571355 Enhanced multi-stress tolerance and glucose utilization of Saccharomycescerevisiae by overexpression of the SNF1 gene and varied beta isoform of Snf1dominates in stresses Meng L, Liu HL, ..., Liu SX 10.1186/s12934-020-01391-4
31372715 Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small Gprotein in Saccharomyces cerevisiae Hayashi N, Oki M 10.1007/s00294-019-01022-5