Product Description: ribosomal protein L41, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.19 | 0.88 |
| Schizont | possibly expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0604200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.393 | MFS: -3.536 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSP0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102880
Most Similar Human Ortholog: Q8IXM3
TM-align score: 0.71 | RMSD: 2.57
Seq Identity: 0.32 | Length: 84 / 93
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000182154 | mitochondrial ribosomal protein L41 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 5 | 6 |
| disruptive | 0 | 4 | 3 | 10 |
| missense | 0 | 3 | 2 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 5 | 3 |
| disruptive | 2 | 14 | 9 | 18 |
| missense | 0 | 11 | 8 | 13 |
PlasmoDB Total SNPs: 60
Non-coding: 55 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 93 | Molecular Weight (kDa): 10.404
UniProt ID(s): C6KSP0
PDB ID(s): None
Isoelectric Point: 11.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019189 | Ribosomal protein L27/L41, mitochondrial |
| PFam | PF09809 | Ribosomal protein L27/L41, mitochondrial |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31339607 | Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. | Lacombe A, Maclean AE, ..., Sheiner L | 10.1111/mmi.14357 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |