About Gene List

PF3D7_0604300

Genome location: Pf3D7_06_v3:181,680..184,760(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.15 0.92
Trophozoite not expressed 0.45 0.73
Schizont not expressed 0.33 0.79
Gametocyte not expressed 0.42 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0604300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.697 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSP1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533591

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 43 25 38
disruptive 54 137 73 140
missense 28 102 59 107

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 77 35 47
disruptive 101 277 117 226
missense 53 199 88 127

PlasmoDB Total SNPs: 179

Non-coding: 57 | Synonymous: 70 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 773 | Molecular Weight (kDa): 91.57

UniProt ID(s): C6KSP1

PDB ID(s): None

Isoelectric Point: 7.02

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104