About Gene List

PF3D7_0604400

Genome location: Pf3D7_06_v3:184,892..185,843(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MNICYLFIYMLCLFMLHG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite possibly expressed 0.01 1.00
Schizont not expressed 0.01 0.99
Gametocyte expressed 0.47 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0604400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.49 | MFS: -2.574 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSP2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146064

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 14 8 13
disruptive 4 12 5 29
missense 4 11 4 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 24 9 12
disruptive 10 30 20 43
missense 7 18 20 32

PlasmoDB Total SNPs: 49

Non-coding: 38 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 178 | Molecular Weight (kDa): 21.657

UniProt ID(s): C6KSP2

PDB ID(s): None

Isoelectric Point: 10.28

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895