PF3D7_0604800

Genome location: Pf3D7_06_v3:206,807..211,802(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	expressed	0.22	0.87
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.48	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0604800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -3.198 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSP6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533122

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	58	36	62
disruptive	51	164	104	229
missense	28	145	95	197

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	95	53	89
disruptive	86	334	151	292
missense	47	287	137	222

PlasmoDB Total SNPs: 156

Non-coding: 46 | Synonymous: 60 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1434 | Molecular Weight (kDa): 172.147

UniProt ID(s): C6KSP6

PDB ID(s): None

Isoelectric Point: 8.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A