Product Description: 50S ribosomal protein L24, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.14 | 0.91 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | possibly expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0605000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -2.949 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1438800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSP8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101141
Most Similar Human Ortholog: Q96A35
TM-align score: 0.67 | RMSD: 3.42
Seq Identity: 0.25 | Length: 160 / 194
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143314 | mitochondrial ribosomal protein L24 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 6 | 9 |
| disruptive | 0 | 8 | 4 | 11 |
| missense | 0 | 8 | 4 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 19 | 4 | 8 |
| disruptive | 4 | 21 | 10 | 42 |
| missense | 1 | 17 | 6 | 24 |
PlasmoDB Total SNPs: 17
Non-coding: 12 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 194 | Molecular Weight (kDa): 22.861
UniProt ID(s): C6KSP8
PDB ID(s): None
Isoelectric Point: 10.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003256 | Ribosomal protein L24 |
| InterPro | IPR005824 | KOW |
| InterPro | IPR005825 | Ribosomal protein L24/L26, conserved site |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR041988 | Ribosomal protein L26/L24, KOW domain |
| PFam | PF00467 | KOW |
| PFam | PF17136 | Ribosomal protein L24 |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |