Product Description: KH domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:1990247 | N6-methyladenosine-containing RNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0010468 | regulation of gene expression |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.50 | 0.76 |
| Trophozoite | expressed | 0.34 | 0.80 |
| Schizont | expressed | 0.39 | 0.74 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0605100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.597 | MFS: -2.506 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSP9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103287
Most Similar Human Ortholog: J3QT27
TM-align score: 0.57 | RMSD: 4.81
Seq Identity: 0.18 | Length: 239 / 755
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000183570 | poly(rC) binding protein 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 32 | 17 | 40 |
| disruptive | 19 | 43 | 29 | 72 |
| missense | 4 | 36 | 27 | 63 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 72 | 17 | 39 |
| disruptive | 33 | 107 | 61 | 139 |
| missense | 9 | 81 | 47 | 106 |
PlasmoDB Total SNPs: 291
Non-coding: 231 | Synonymous: 44 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 755 | Molecular Weight (kDa): 85.631
UniProt ID(s): C6KSP9
PDB ID(s): None
Isoelectric Point: 6.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004087 | K Homology domain |
| InterPro | IPR004088 | K Homology domain, type 1 |
| InterPro | IPR036612 | K Homology domain, type 1 superfamily |
| PFam | PF00013 | K Homology domain, type 1 |
| Superfamily | SSF54791 | K Homology domain, type 1 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |