PF3D7_0605200

Genome location: Pf3D7_06_v3:220,100..221,977(-)

Genome classification: Core

Function and Localization

Product Description: acylphosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.1.7 (Acylphosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	expressed	0.38	0.76
Schizont	expressed	0.19	0.87
Gametocyte	expressed	0.44	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0605200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0104000)

Relative Growth Rate: 0.13 ± 0.07
Confidence: 6.83

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSQ0

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.1.7	acylphosphatase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139472

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	13	6	18
disruptive	1	7	9	19
missense	1	7	9	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	27	12	19
disruptive	1	28	18	46
missense	1	22	18	39

PlasmoDB Total SNPs: 127

Non-coding: 115 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 209 | Molecular Weight (kDa): 25.373

UniProt ID(s): C6KSQ0

PDB ID(s): None

Isoelectric Point: 10.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21