PF3D7_0605500

Genome location: Pf3D7_06_v3:225,346..227,905(-)

Genome classification: Core

Function and Localization

Product Description: cyclin dependent kinase binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0051726	regulation of cell cycle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.03	0.99
Trophozoite	expressed	0.13	0.91
Schizont	expressed	0.12	0.91
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0605500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.207 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0104300)

Relative Growth Rate: 0.91 ± 0.17
Confidence: 4.89

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0104300)

Modification: Disrupted | RMgm-1617

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSQ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103855

Most Similar Human Ortholog: J3QRY5

TM-align score: 0.47 | RMSD: 1.56

Seq Identity: 0.00 | Length: 27 / 607

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000134508	Cdk5 and Abl enzyme substrate 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	20	19	40
disruptive	12	60	39	63
missense	7	48	30	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	46	29	48
disruptive	32	102	54	109
missense	18	74	42	85

PlasmoDB Total SNPs: 93

Non-coding: 54 | Synonymous: 26 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 607 | Molecular Weight (kDa): 72.621

UniProt ID(s): C6KSQ3

PDB ID(s): None

Isoelectric Point: 9.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006671	Cyclin, N-terminal
InterPro	IPR012388	CDK5 and ABL1 enzyme substrate 1/2
InterPro	IPR013763	Cyclin-like
InterPro	IPR036915	Cyclin-like superfamily
PFam	PF00134	Cyclin, N-terminal
Superfamily	SSF47954	Cyclin-like superfamily