Product Description: elongation of fatty acids protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: 2.3.1.199 (Very-long-chain 3-oxoacyl-CoA synthase);6.2.1.3 (Long-chain-fatty-acid--CoA ligase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Component | GO:0016021 | integral component of membrane |
| Function | GO:0009922 | fatty acid elongase activity |
| Process | GO:0034625 | fatty acid elongation, monounsaturated fatty acid |
| Process | GO:0034626 | fatty acid elongation, polyunsaturated fatty acid |
| Process | GO:0019367 | fatty acid elongation, saturated fatty acid |
| Process | GO:0019368 | fatty acid elongation, unsaturated fatty acid |
| Process | GO:0030148 | sphingolipid biosynthetic process |
| Process | GO:0042761 | very long-chain fatty acid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.71 | 0.67 |
| Trophozoite | expressed | 0.14 | 0.91 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0605900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.164 | MFS: -2.845 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0104700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0104700)
Modification: Disrupted | RMgm-1619
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSQ7
"Best" AlphaFill ligand hit: 37X (octyl glucose neopentyl glycol, Local RMSD=0.02) with 6Y7F (Global RMSD=5.17)
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9BW60 | Elongation of very long chain fatty acids protein 1 | Homo sapiens | OrthoDB | CHEMBL570571CHEMBL5090501CHEMBL5075747CHEMBL5081977... |
Ortholog Group (OrthoMCL): OG6_100254
Most Similar Human Ortholog: D6RHD0
TM-align score: 0.82 | RMSD: 2.71
Seq Identity: 0.27 | Length: 247 / 293
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000012660 | ELOVL fatty acid elongase 5 |
| ENSG00000118402 | ELOVL fatty acid elongase 4 |
| ENSG00000164181 | ELOVL fatty acid elongase 7 |
Protein Length: 293 | Molecular Weight (kDa): 34.732
UniProt ID(s): C6KSQ7
PDB ID(s): None
Isoelectric Point: 10.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002076 | ELO family |
| PFam | PF01151 | ELO family |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 6 | 19 |
| disruptive | 0 | 6 | 4 | 13 |
| missense | 0 | 5 | 3 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 30 | 15 | 22 |
| disruptive | 5 | 24 | 18 | 43 |
| missense | 2 | 15 | 15 | 29 |
PlasmoDB Total SNPs: 261
Non-coding: 248 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22179608 | Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis inapicomplexan parasite Toxoplasma gondii. | Ramakrishnan S, Docampo MD, ..., Striepen B | 10.1074/jbc.M111.310144 |