Product Description: protein KIC1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.84 | 0.31 |
| Trophozoite | expressed | 0.68 | 0.64 |
| Schizont | expressed | 0.99 | 0.47 |
| Gametocyte | expressed | 0.63 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0606000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.96 | MFS: -2.925 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSQ8
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.28) with 5OXF (Global RMSD=29.51)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 62 | 32 | 73 |
| disruptive | 57 | 228 | 136 | 263 |
| missense | 41 | 201 | 118 | 230 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 36 | 106 | 58 | 89 |
| disruptive | 116 | 489 | 161 | 344 |
| missense | 88 | 396 | 134 | 236 |
PlasmoDB Total SNPs: 322
Non-coding: 202 | Synonymous: 52 | Nonsynonymous: 67 | Stop Codon: 1
Protein Length: 1063 | Molecular Weight (kDa): 123.332
UniProt ID(s): C6KSQ8
PDB ID(s): None
Isoelectric Point: 5.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 12480907 | The protein kinase Kic1 affects 1,6-beta-glucan levels in the cell wall ofSaccharomyces cerevisiae | Vink E, Vossen JH, ..., Klis FM | 10.1099/00221287-148-12-4035 |
| 9813095 | The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, arerequired for cell integrity | Sullivan DS, Biggins S, Rose MD | 10.1083/jcb.143.3.751 |
| 19967545 | Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomycescerevisiae, make the protein independent of upstream activators | Panozzo C, Bourens M, Nowacka A, Herbert CJ | 10.1007/s00438-009-0501-3 |
| 35402407 | Identification of Kic1p and Cdc42p as Novel Targets to Engineer Yeast Acetic AcidStress Tolerance | Chen HQ, Xing Q, ..., Zhao XQ | 10.3389/fbioe.2022.837813 |
| 12565823 | The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue thatregulates cell-cell separation | Tang Z, Mandel LL, ..., Lin RJ | 10.1016/s0014-4827(02)00022-8 |
| 21880084 | Genome-wide association analysis of clinical vs. nonclinical origin providesinsights into Saccharomyces cerevisiae pathogenesis | Muller LA, Lucas JE, Georgianna DR, McCusker JH | 10.1111/j.1365-294X.2011.05225.x |
| 11156974 | Fine structure analysis of the yeast centrin, Cdc31p, identifies residuesspecific for cell morphology and spindle pole body duplication | Ivanovska I, Rose MD | 10.1093/genetics/157.2.503 |
| 12454058 | High-resolution genetic mapping with ordered arrays of Saccharomyces cerevisiaedeletion mutants | Jorgensen P, Nelson B, ..., Boone C | 10.1093/genetics/162.3.1091 |
| 15311284 | Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery | Fischer T, Rodriguez-Navarro S, ..., Hurt E | 10.1038/ncb1163 |
| 24205201 | Cell cycle regulated interaction of a yeast Hippo kinase and its activatorMO25/Hym1 | Hsu J, Weiss EL | 10.1371/journal.pone.0078334 |