PF3D7_0606100

Genome location: Pf3D7_06_v3:257,163..260,505(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0032021	NELF complex
Function	GO:0003723	RNA binding
Process	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.11	0.50
Trophozoite	expressed	1.01	0.48
Schizont	expressed	0.42	0.75
Gametocyte	expressed	0.92	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0606100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.572 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0104900)

Relative Growth Rate: 0.36 ± 0.11
Confidence: 5.87

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0104900)

Modification: Disrupted | RMgm-1621

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSQ9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_185459

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	35	27	40
disruptive	36	89	50	107
missense	18	63	48	88

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	75	20	45
disruptive	57	178	83	202
missense	24	142	71	134

PlasmoDB Total SNPs: 224

Non-coding: 165 | Synonymous: 34 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 582 | Molecular Weight (kDa): 67.9

UniProt ID(s): C6KSQ9

PDB ID(s): None

Isoelectric Point: 10.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR033102	Negative elongation factor E
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily