PF3D7_0606400

Genome location: Pf3D7_06_v3:263,936..264,830(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.01	1.00
Gametocyte	no data	0.55	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0606400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -3.026 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0105100)

Relative Growth Rate: 1.05 ± 0.15
Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0105100)

Modification: Disrupted | RMgm-1622

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSR2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533424

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	0	8
disruptive	2	6	5	12
missense	2	6	5	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	9	9	8
disruptive	3	17	10	26
missense	2	12	8	17

PlasmoDB Total SNPs: 37

Non-coding: 35 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 125 | Molecular Weight (kDa): 14.63

UniProt ID(s): C6KSR2

PDB ID(s): None

Isoelectric Point: 4.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A