PF3D7_0606600

Genome location: Pf3D7_06_v3:270,150..279,739(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000932	P-body
Component	GO:0005634	nucleus
Process	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.72	0.34
Trophozoite	expressed	1.06	0.47
Schizont	expressed	0.49	0.73
Gametocyte	expressed	1.12	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0606600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.271 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0105300)

Modification: Disrupted | RMgm-1624

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSR4

"Best" AlphaFill ligand hit: DCP (2'-deoxycytidine-5'-triphosphate, Local RMSD=2.51) with 4PTF (Global RMSD=19.97)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533458

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	105	64	130
disruptive	159	317	181	431
missense	76	223	153	338

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	47	207	100	141
disruptive	232	670	312	598
missense	106	489	246	416

PlasmoDB Total SNPs: 537

Non-coding: 162 | Synonymous: 177 | Nonsynonymous: 198 | Stop Codon: 0

Protein Information

Protein Length: 2414 | Molecular Weight (kDa): 280.362

UniProt ID(s): C6KSR4

PDB ID(s): None

Isoelectric Point: 4.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108