Product Description: coatomer alpha subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030126 | COPI vesicle coat |
| Component | GO:0005634 | nucleus |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.84 | 0.61 |
| Trophozoite | expressed | 1.04 | 0.47 |
| Schizont | expressed | 0.92 | 0.52 |
| Gametocyte | possibly expressed | 0.86 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0606700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.102 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0105400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSR5
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.01) with 6Y7O (Global RMSD=2.89)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O75530 | Polycomb protein EED | OrthoMCL BLAST | CHEMBL4104741rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (1)rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (2)(3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine (3)... |
Ortholog Group (OrthoMCL): OG6_101600
Most Similar Human Ortholog: A0A3B3ISK1
TM-align score: 0.76 | RMSD: 4.15
Seq Identity: 0.51 | Length: 404 / 1512
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000122218 | COPI coat complex subunit alpha |
Protein Length: 1512 | Molecular Weight (kDa): 176.946
UniProt ID(s): C6KSR5
PDB ID(s): None
Isoelectric Point: 8.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR006692 | Coatomer, WD associated region |
| InterPro | IPR010714 | Coatomer, alpha subunit, C-terminal |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF04053 | Coatomer, WD associated region |
| PFam | PF06957 | Coatomer, alpha subunit, C-terminal |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 86 | 51 | 97 |
| disruptive | 27 | 95 | 77 | 170 |
| missense | 12 | 86 | 74 | 150 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 167 | 58 | 96 |
| disruptive | 55 | 226 | 116 | 312 |
| missense | 25 | 193 | 104 | 237 |
PlasmoDB Total SNPs: 220
Non-coding: 129 | Synonymous: 64 | Nonsynonymous: 27 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |