Product Description: VFT protein
SignalP Peptide: MMHIFCKLFLFFSFVYI
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.11 | 0.95 |
| Trophozoite | no data | 0.42 | 0.75 |
| Schizont | no data | 0.32 | 0.81 |
| Gametocyte | no data | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0606800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -2.931 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSR6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 18 | 5 | 19 |
| disruptive | 1 | 7 | 9 | 29 |
| missense | 1 | 6 | 9 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 30 | 14 | 19 |
| disruptive | 1 | 34 | 22 | 45 |
| missense | 1 | 28 | 19 | 38 |
PlasmoDB Total SNPs: 133
Non-coding: 115 | Synonymous: 14 | Nonsynonymous: 1 | Stop Codon: 3
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16203726 | Distinct protein classes including novel merozoite surface antigens in Raft-likemembranes of Plasmodium falciparum. | Sanders PR, Gilson PR, ..., Crabb BS | 10.1074/jbc.M509631200 |