PF3D7_0606900 (GLP2)

Genome location: Pf3D7_06_v3:290,146..292,628(-)

Genome classification: Core

Function and Localization

Product Description: glutaredoxin-like protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 1.8.4.2 (Protein-disulfide reductase (glutathione))

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0606900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.051 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0105500)

• Relative Growth Rate: 0.23 ± 0.08
• Confidence: 6.38

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0105500)

Modification: Disrupted | RMgm-1626

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSR7

"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=0.39) with 2YAN (Global RMSD=0.86)

BRENDA EC Inhibitors:

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101660

Most Similar Human Ortholog: O76003

TM-align score: 0.50 | RMSD: 1.77

Seq Identity: 0.36 | Length: 116 / 219

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 98

Non-coding: 83 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 219 | Molecular Weight (kDa): 26.035

UniProt ID(s): C6KSR7

PDB ID(s): None

Isoelectric Point: 5.41

Protein Domain Annotations: