Product Description: translation initiation factor IF-2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.41 | 0.41 |
| Trophozoite | expressed | 1.71 | 0.25 |
| Schizont | expressed | 0.61 | 0.66 |
| Gametocyte | expressed | 0.89 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0607000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.159 | MFS: -2.74 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0105600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSR8
"Best" AlphaFill ligand hit: PPV (pyrophosphate, Local RMSD=0.08) with 2PMD (Global RMSD=6.62)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101241
Most Similar Human Ortholog: O60841
TM-align score: 0.67 | RMSD: 4.68
Seq Identity: 0.46 | Length: 731 / 977
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000158417 | eukaryotic translation initiation factor 5B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 39 | 25 | 50 |
| disruptive | 10 | 34 | 33 | 79 |
| missense | 7 | 28 | 28 | 55 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 88 | 36 | 59 |
| disruptive | 31 | 97 | 62 | 135 |
| missense | 15 | 64 | 50 | 97 |
PlasmoDB Total SNPs: 282
Non-coding: 234 | Synonymous: 43 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 977 | Molecular Weight (kDa): 112.358
UniProt ID(s): C6KSR8
PDB ID(s): None
Isoelectric Point: 8.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000795 | Transcription factor, GTP-binding domain |
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR015760 | Translation initiation factor IF- 2 |
| InterPro | IPR023115 | Translation initiation factor IF- 2, domain 3 |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036925 | Translation initiation factor IF-2, domain 3 superfamily |
| PFam | PF00009 | Transcription factor, GTP-binding domain |
| PFam | PF11987 | Translation initiation factor IF- 2, domain 3 |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| Superfamily | SSF52156 | Translation initiation factor IF-2, domain 3 superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |