Product Description: MYND-type zinc finger protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.01 | 0.99 |
| Trophozoite | no data | 0.02 | 0.99 |
| Schizont | no data | 0.01 | 1.00 |
| Gametocyte | no data | 0.49 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0607100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.895 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0105700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0105700)
Modification: Disrupted | RMgm-4197
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSR9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104592
Most Similar Human Ortholog: C9JUQ8
TM-align score: 0.79 | RMSD: 3.52
Seq Identity: 0.21 | Length: 266 / 472
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000004838 | zinc finger MYND-type containing 10 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 33 | 16 | 24 |
| disruptive | 6 | 51 | 35 | 77 |
| missense | 6 | 50 | 35 | 70 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 48 | 23 | 41 |
| disruptive | 22 | 103 | 68 | 120 |
| missense | 17 | 89 | 60 | 91 |
PlasmoDB Total SNPs: 287
Non-coding: 251 | Synonymous: 25 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 472 | Molecular Weight (kDa): 57.438
UniProt ID(s): C6KSR9
PDB ID(s): None
Isoelectric Point: 6.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002893 | Zinc finger, MYND-type |
| PFam | PF01753 | Zinc finger, MYND-type |
| Superfamily | SSF144232 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |