PF3D7_0607200

Genome location: Pf3D7_06_v3:301,304..303,478(-)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.98
Trophozoite	no data	0.30	0.81
Schizont	no data	0.09	0.94
Gametocyte	no data	0.78	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0607200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.102 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0105800)

Relative Growth Rate: 0.98 ± 0.16
Confidence: 5.07

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0105800)

Modification: Disrupted | RMgm-1628

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSS0

"Best" AlphaFill ligand hit: CPQ (n,n-bis(3-d-gluconamidopropyl)deoxycholamide, Local RMSD=2.94) with 4AYC (Global RMSD=11.38)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130930

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	19	13	17
disruptive	3	17	10	47
missense	3	17	10	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	28	17	29
disruptive	9	62	52	110
missense	4	47	42	71

PlasmoDB Total SNPs: 117

Non-coding: 97 | Synonymous: 19 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 429 | Molecular Weight (kDa): 50.861

UniProt ID(s): C6KSS0

PDB ID(s): None

Isoelectric Point: 8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR011016	Zinc finger, RING-CH-type
PFam	PF13639	Zinc finger, RING-type
Superfamily	SSF57850	N/A