Product Description: uroporphyrinogen III decarboxylase
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 4.1.1.37 (Uroporphyrinogen decarboxylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005829 | cytosol |
| Function | GO:0004853 | uroporphyrinogen decarboxylase activity |
| Process | GO:0006783 | heme biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.14 | 0.92 |
| Schizont | possibly expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0607300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -2.261 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0105900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0105900)
Modification: Disrupted | RMgm-1629
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSS1
"Best" AlphaFill ligand hit: BU2 (1,3-butanediol, Local RMSD=0.87) with 4W50 (Global RMSD=13.62)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.1.1.37 | uroporphyrinogen decarboxylase | O2KClNEMSDSPCMBPI-16oleateHaeminethanolacetonemethanollinolate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100829
Most Similar Human Ortholog: A0A494BZY8
TM-align score: 0.93 | RMSD: 1.61
Seq Identity: 0.32 | Length: 281 / 413
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126088 | uroporphyrinogen decarboxylase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 7 | 26 |
| disruptive | 2 | 19 | 20 | 56 |
| missense | 2 | 19 | 19 | 45 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 33 | 25 | 33 |
| disruptive | 5 | 59 | 41 | 103 |
| missense | 3 | 48 | 33 | 76 |
PlasmoDB Total SNPs: 141
Non-coding: 112 | Synonymous: 22 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 413 | Molecular Weight (kDa): 48.833
PDB ID(s): None
Isoelectric Point: 8.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000257 | Uroporphyrinogen decarboxylase (URO-D) |
| InterPro | IPR006361 | Uroporphyrinogen decarboxylase HemE |
| InterPro | IPR038071 | UROD/MetE-like superfamily |
| PFam | PF01208 | Uroporphyrinogen decarboxylase (URO-D) |
| Superfamily | SSF51726 | UROD/MetE-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19041871 | Localisation of Plasmodium falciparum uroporphyrinogen III decarboxylase of theheme-biosynthetic pathway in the apicoplast and characterisation of its catalyticproperties. | Nagaraj VA, Arumugam R, ..., Padmanaban G | 10.1016/j.ijpara.2008.10.011 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |