Product Description: G-protein associated signal transduction protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016020 | membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0000822 | inositol hexakisphosphate binding |
| Function | GO:0015114 | phosphate ion transmembrane transporter activity |
| Process | GO:0016036 | cellular response to phosphate starvation |
| Process | GO:0006817 | phosphate ion transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.18 | 0.91 |
| Trophozoite | no data | 0.56 | 0.68 |
| Schizont | no data | 0.16 | 0.89 |
| Gametocyte | no data | 0.74 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0607400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.105 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0106000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0106000)
Modification: Disrupted | RMgm-1630
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSS2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100965
Most Similar Human Ortholog: Q9UBH6
TM-align score: 0.57 | RMSD: 4.90
Seq Identity: 0.22 | Length: 434 / 633
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143324 | xenotropic and polytropic retrovirus receptor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 36 | 23 | 36 |
| disruptive | 1 | 13 | 13 | 46 |
| missense | 1 | 13 | 11 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 68 | 30 | 51 |
| disruptive | 9 | 66 | 49 | 170 |
| missense | 3 | 46 | 32 | 121 |
PlasmoDB Total SNPs: 283
Non-coding: 253 | Synonymous: 29 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 633 | Molecular Weight (kDa): 76.18
UniProt ID(s): C6KSS2
PDB ID(s): None
Isoelectric Point: 9.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004342 | EXS, C-terminal |
| InterPro | IPR033507 | Syg1 family |
| PFam | PF03124 | EXS, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |