Product Description: 4-hydroxybenzoate polyprenyltransferase
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: 2.5.1.39 (4-hydroxybenzoate polyprenyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031305 | integral component of mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008412 | 4-hydroxybenzoate octaprenyltransferase activity |
| Function | GO:0002094 | polyprenyltransferase activity |
| Function | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| Process | GO:0006744 | ubiquinone biosynthetic process |
| Process | GO:0006743 | ubiquinone metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.04 | 0.98 |
| Trophozoite | no data | 0.15 | 0.90 |
| Schizont | no data | 0.07 | 0.95 |
| Gametocyte | no data | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0607500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.119 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0106100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KSS3
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase | KCNNaFBrij W1Tween 80acetyl-CoAbacitracinTriton X-100deoxycholateNonidet P-40iodoacetamidepalmitoyl-CoADiphenylamine... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101249
Most Similar Human Ortholog: H0YAI0
TM-align score: 0.89 | RMSD: 1.95
Seq Identity: 0.34 | Length: 221 / 521
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000173085 | coenzyme Q2, polyprenyltransferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 25 | 14 | 35 |
| disruptive | 19 | 61 | 34 | 75 |
| missense | 17 | 51 | 31 | 64 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 54 | 22 | 41 |
| disruptive | 42 | 140 | 67 | 178 |
| missense | 27 | 112 | 48 | 90 |
PlasmoDB Total SNPs: 192
Non-coding: 183 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 521 | Molecular Weight (kDa): 62.268
UniProt ID(s): C6KSS3
PDB ID(s): None
Isoelectric Point: 9.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000537 | UbiA prenyltransferase family |
| InterPro | IPR030470 | UbiA prenyltransferase conserved site |
| InterPro | IPR039653 | Prenyltransferase |
| PFam | PF01040 | UbiA prenyltransferase family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16774588 | Metabolic maps and functions of the Plasmodium mitochondrion. | van Dooren GG, Stimmler LM, McFadden GI | https://pubmed.ncbi.nlm.nih.gov/16774588/ |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37291700 | Plasmodium falciparum COQ2 gene encodes a functional 4-hydroxybenzoatepolyprenyltransferase | Zafra CA, Crispim M, ..., Hernandez A | 10.1093/femsle/fnad050 |