PF3D7_0607700

Genome location: Pf3D7_06_v3:319,519..329,442(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.41	0.81
Schizont	expressed	1.66	0.40
Gametocyte	expressed	1.63	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0607700

Resistome Missense Mutations: D170Y, N1097K

Resistome Compounds with Missense Mutations: AN13762, AN13956, Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 10 (9 missense, 9 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.978 | #Insertions: 8

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0106300)

Relative Growth Rate: 0.80 ± 0.15
Confidence: 5.24

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0106300)

Modification: Disrupted | RMgm-1633

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156452

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	25	130	59	149
disruptive	152	389	214	571
missense	80	319	165	432

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	41	259	118	194
disruptive	250	945	433	939
missense	134	691	314	549

PlasmoDB Total SNPs: 529

Non-coding: 138 | Synonymous: 170 | Nonsynonymous: 221 | Stop Codon: 0

Protein Information

Protein Length: 2752 | Molecular Weight (kDa): 325.017

UniProt ID(s): C6KSS5

PDB ID(s): None

Isoelectric Point: 7.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025677	OST-HTH associated domain
InterPro	IPR036465	von Willebrand factor A-like domain superfamily
PFam	PF14418	OST-HTH associated domain
Superfamily	SSF53300	von Willebrand factor A-like domain superfamily