PF3D7_0607800

Genome location: Pf3D7_06_v3:329,254..332,013(-)

Genome classification: Core

Function and Localization

Product Description: GTP-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.93
Trophozoite	expressed	0.22	0.87
Schizont	possibly expressed	0.04	0.98
Gametocyte	possibly expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0607800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -0.733 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0106400)

Relative Growth Rate: 0.10 ± 0.08
Confidence: 6.47

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSS6

"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=0.49) with 6IF2 (Global RMSD=3.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532823

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	33	17	37
disruptive	9	58	34	95
missense	8	51	29	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	61	19	47
disruptive	26	136	70	160
missense	15	107	59	107

PlasmoDB Total SNPs: 145

Non-coding: 52 | Synonymous: 56 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 674 | Molecular Weight (kDa): 77.689

UniProt ID(s): C6KSS6

PDB ID(s): None

Isoelectric Point: 6.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006169	GTP1/OBG domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR036726	GTP1/OBG domain superfamily
PFam	PF01018	GTP1/OBG domain
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase
Superfamily	SSF57997	GTP1/OBG domain superfamily
Superfamily	SSF82051

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21