About Gene List

PF3D7_0607900

Genome location: Pf3D7_06_v3:332,329..335,631(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0030687 preribosome, large subunit precursor
Function GO:0019843 rRNA binding
Process GO:0000027 ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.35 0.85
Trophozoite expressed 0.59 0.68
Schizont expressed 0.16 0.91
Gametocyte possibly expressed 0.97 0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0607900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.932 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSS7

"Best" AlphaFill ligand hit: LPA (lipoic acid, Local RMSD=0.60) with 5T8U (Global RMSD=20.86)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533084

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 33 27 46
disruptive 22 100 50 161
missense 16 85 45 140

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 79 36 54
disruptive 47 205 106 263
missense 32 161 85 184

PlasmoDB Total SNPs: 97

Non-coding: 23 | Synonymous: 52 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 863 | Molecular Weight (kDa): 104.034

UniProt ID(s): C6KSS7

PDB ID(s): None

Isoelectric Point: 4.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895