About Gene List

PF3D7_0608100

Genome location: Pf3D7_06_v3:336,465..342,148(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKYQLFIALIVLLNVCFS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.24 0.88
Trophozoite expressed 1.32 0.39
Schizont expressed 0.35 0.81
Gametocyte expressed 0.59 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0608100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.145 | MFS: -2.851 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0106700)

  • Relative Growth Rate: 0.13 ± 0.11
  • Confidence: 5.79

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSS9

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.71) with 6JWQ (Global RMSD=26.33)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_155931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 44 28 75
disruptive 72 125 95 223
missense 37 99 84 174

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 82 53 87
disruptive 109 313 148 299
missense 48 236 118 219

PlasmoDB Total SNPs: 198

Non-coding: 50 | Synonymous: 92 | Nonsynonymous: 54 | Stop Codon: 2

Protein Information

Protein Length: 1322 | Molecular Weight (kDa): 157.629

UniProt ID(s): C6KSS9

PDB ID(s): None

Isoelectric Point: 6.89

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895