PF3D7_0608200

Genome location: Pf3D7_06_v3:341,804..342,871(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.21	0.87
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0608200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.155 | MFS: -3.072 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KST0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532729

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	10	2	7
disruptive	2	9	5	17
missense	2	8	5	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	15	3	10
disruptive	5	29	20	41
missense	3	20	18	25

PlasmoDB Total SNPs: 71

Non-coding: 61 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 156 | Molecular Weight (kDa): 19.116

UniProt ID(s): C6KST0

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A