PF3D7_0608300

Genome location: Pf3D7_06_v3:342,351..347,812(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.16	0.92
Trophozoite	expressed	0.88	0.55
Schizont	expressed	0.14	0.92
Gametocyte	expressed	0.94	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0608300

Resistome Missense Mutations: Q1357K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -3.232 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0106900)

Relative Growth Rate: 0.12 ± 0.12
Confidence: 5.59

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KST1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533584

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	38	37	81
disruptive	76	161	81	198
missense	51	112	65	165

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	102	53	86
disruptive	151	332	145	328
missense	87	234	107	204

PlasmoDB Total SNPs: 250

Non-coding: 49 | Synonymous: 84 | Nonsynonymous: 117 | Stop Codon: 0

Protein Information

Protein Length: 1431 | Molecular Weight (kDa): 171.022

UniProt ID(s): A0A0N7EJ21, C6KST1

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A