Product Description: sorting assembly machinery 50 kDa subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0001401 | SAM complex |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0034622 | cellular protein-containing complex assembly |
| Process | GO:0045040 | protein insertion into mitochondrial outer membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.13 | 0.92 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0608310
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.17 | MFS: -3.28 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZW95
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102372
Most Similar Human Ortholog: Q9Y512
TM-align score: 0.82 | RMSD: 2.83
Seq Identity: 0.17 | Length: 412 / 453
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100347 | SAMM50 sorting and assembly machinery component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 12 | 8 | 30 |
| disruptive | 5 | 17 | 15 | 45 |
| missense | 5 | 17 | 14 | 40 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 36 | 19 | 21 |
| disruptive | 8 | 62 | 44 | 74 |
| missense | 6 | 49 | 35 | 40 |
PlasmoDB Total SNPs: 75
Non-coding: 56 | Synonymous: 15 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 453 | Molecular Weight (kDa): 53.722
UniProt ID(s): A0A0N7EJ21, A0A143ZW95
PDB ID(s): None
Isoelectric Point: 9.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR039910 | Surface antigen D15-like |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26381927 | Toxoplasma gondii Toc75 Functions in Import of Stromal but not PeripheralApicoplast Proteins. | Sheiner L, Fellows JD, ..., Striepen B | 10.1111/tra.12333 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37723586 | Yeast mitochondria can process de novo designed beta-barrel proteins | Moitra A, Tiku V, Rapaport D | 10.1111/febs.16950 |