Product Description: proteasome subunit alpha type-2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.25.1 (Proteasome endopeptidase complex)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Component | GO:0005839 | proteasome core complex |
| Component | GO:0019773 | proteasome core complex, alpha-subunit complex |
| Function | GO:0004175 | endopeptidase activity |
| Process | GO:0010498 | proteasomal protein catabolic process |
| Process | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process |
| Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.91 |
| Trophozoite | expressed | 0.57 | 0.67 |
| Schizont | expressed | 0.22 | 0.85 |
| Gametocyte | expressed | 0.18 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0608500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.1 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0107100)
Modification: Disrupted | RMgm-1639
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KST3
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.25.1 | proteasome endopeptidase complex | ATPSDSPSIEDTANH4+EGTATLCKALLNNMDANLVSPI 1PA28... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P23639 | Proteasome subunit alpha type-2 | HOGENOM, OMA, OrthoDB, OrthoMCL | Carmaphycin A (1)(2S)-N-[(4S)-2,6-dimethyl-3-oxohept-1-en-4-yl]-2-[(2S)-2-hexanamido-3-methylbutanamido]-N',N'-dimethylpentanediamide (4)(2S)-N-[(4S)-2,6-dimethyl-3-oxohept-1-en-4-yl]-2-[(2S)-2-hexanamido-3-methylbutanamido]-N',N'-dimethylpentanediamide (4)Carmaphycin A (1)... | |
| P60900 | Proteasome subunit alpha type-6 | OrthoDB | cid_66069med.21724, Compound 15CPZ analog, 2CPZ analog, 5... | |
| P25786 | Proteasome subunit alpha type-1 | OrthoDB | CHEMBL4872258CHEMBL4877708 |
Ortholog Group (OrthoMCL): OG6_101969
Most Similar Human Ortholog: A0A024RA52
TM-align score: 0.98 | RMSD: 0.85
Seq Identity: 0.58 | Length: 234 / 235
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000106588 | proteasome 20S subunit alpha 2 |
| ENSG00000256646 | UPF0415 protein C7orf25 |
Protein Length: 235 | Molecular Weight (kDa): 26.528
UniProt ID(s): C6KST3
PDB ID(s): 5FMG
Isoelectric Point: 5.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000426 | Proteasome alpha-subunit, N-terminal domain |
| InterPro | IPR001353 | Proteasome, subunit alpha/beta |
| InterPro | IPR029055 | Nucleophile aminohydrolases, N-terminal |
| InterPro | IPR034644 | Proteasome subunit alpha2 |
| PFam | PF00227 | Proteasome, subunit alpha/beta |
| PFam | PF10584 | Proteasome alpha-subunit, N-terminal domain |
| Superfamily | SSF56235 | Nucleophile aminohydrolases, N-terminal |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 1 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 217
Non-coding: 211 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33608523 | 20S proteasomes secreted by the malaria parasite promote its growth. | Dekel E, Yaffe D, ..., Regev-Rudzki N | 10.1038/s41467-021-21344-8 |