PF3D7_0608600

Genome location: Pf3D7_06_v3:354,683..356,424(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.31	0.82
Schizont	not expressed	0.10	0.94
Gametocyte	expressed	1.51	0.37

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0608600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.114 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0107200)

Modification: Disrupted | RMgm-1640

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KST4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533051

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	9	3	11
disruptive	26	31	17	39
missense	10	21	13	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	20	6	17
disruptive	37	69	28	83
missense	16	45	23	47

PlasmoDB Total SNPs: 93

Non-coding: 50 | Synonymous: 20 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 283 | Molecular Weight (kDa): 33.282

UniProt ID(s): C6KST4

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A