Product Description: T-complex protein 1 subunit zeta
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005832 | chaperonin-containing T-complex |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.72 | 0.67 |
| Trophozoite | expressed | 1.09 | 0.46 |
| Schizont | expressed | 0.13 | 0.92 |
| Gametocyte | expressed | 0.75 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0608700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.247 | MFS: -2.844 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0107300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0107300)
Modification: Disrupted | RMgm-1641
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KST5
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.80) with 1Q3Q (Global RMSD=3.78)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101716
Most Similar Human Ortholog: Q92526
TM-align score: 0.98 | RMSD: 1.30
Seq Identity: 0.48 | Length: 529 / 543
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132141 | chaperonin containing TCP1 subunit 6B |
| ENSG00000146731 | chaperonin containing TCP1 subunit 6A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 23 | 15 | 32 |
| disruptive | 0 | 6 | 5 | 24 |
| missense | 0 | 6 | 5 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 56 | 17 | 41 |
| disruptive | 2 | 24 | 18 | 64 |
| missense | 0 | 19 | 15 | 50 |
PlasmoDB Total SNPs: 247
Non-coding: 227 | Synonymous: 17 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 543 | Molecular Weight (kDa): 61.534
UniProt ID(s): C6KST5
PDB ID(s): None
Isoelectric Point: 6.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002194 | Chaperonin TCP-1, conserved site |
| InterPro | IPR002423 | Chaperonin Cpn60/TCP-1 family |
| InterPro | IPR012722 | T-complex protein 1, zeta subunit |
| InterPro | IPR017998 | Chaperone tailless complex polypeptide 1 (TCP-1) |
| InterPro | IPR027409 | GroEL-like apical domain superfamily |
| InterPro | IPR027410 | TCP-1-like chaperonin intermediate domain superfamily |
| InterPro | IPR027413 | GroEL-like equatorial domain superfamily |
| PFam | PF00118 | Chaperonin Cpn60/TCP-1 family |
| Superfamily | SSF48592 | GroEL-like equatorial domain superfamily |
| Superfamily | SSF52029 | GroEL-like apical domain superfamily |
| Superfamily | SSF54849 | TCP-1-like chaperonin intermediate domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25615740 | New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of theParasite Group II Chaperonin, PfTRiC. | Mbengue A, Vialla E, ..., Braun-Breton C | 10.1111/tra.12266 |
| 28067475 | The chaperonin T RiC forms an oligomeric complex in the malaria parasite cytosol | Spillman NJ, Beck JR, ..., Goldberg DE | 10.1111/cmi.12719 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 9380710 | The unique hetero-oligomeric nature of the subunits in the catalyticcooperativity of the yeast Cct chaperonin complex | Lin P, Sherman F | 10.1073/pnas.94.20.10780 |
| 29625202 | Yeast Inner-Subunit PA-NZ-1 Labeling Strategy for Accurate Subunit Identificationin a Macromolecular Complex through Cryo-EM Analysis | Wang H, Han W, Takagi J, Cong Y | 10.1016/j.jmb.2018.03.026 |
| 18680526 | Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomycescerevisiae | Kabir MA, Sherman F | 10.1111/j.1567-1364.2008.00425.x |
| 14504216 | Suppression of a defect in mitochondrial protein import identifies cytosolicproteins required for viability of yeast cells lacking mitochondrial DNA | Dunn CD, Jensen RE | 10.1093/genetics/165.1.35 |
| 8943012 | TOR2 is required for organization of the actin cytoskeleton in yeast | Schmidt A, Kunz J, Hall MN | 10.1073/pnas.93.24.13780 |
| 23112166 | Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-richproteins revealed by high-throughput microscopy analysis | Nadler-Holly M, Breker M, ..., Horovitz A | 10.1073/pnas.1209277109 |
| 15704212 | Physiological effects of unassembled chaperonin Cct subunits in the yeastSaccharomyces cerevisiae | Kabir MA, Kaminska J, ..., Sherman F | 10.1002/yea.1210 |
| 9409825 | Analysis of mutationally altered forms of the Cct6 subunit of the chaperonin fromSaccharomyces cerevisiae | Lin P, Cardillo TS, ..., Sherman F | 10.1093/genetics/147.4.1609 |