Product Description: ornithine aminotransferase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.6.1.13 (Ornithine aminotransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005622 | intracellular |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003723 | RNA binding |
| Function | GO:0042802 | identical protein binding |
| Function | GO:0004587 | ornithine-oxo-acid transaminase activity |
| Function | GO:0005515 | protein binding |
| Function | GO:0030170 | pyridoxal phosphate binding |
| Process | GO:0019544 | arginine catabolic process to glutamate |
| Process | GO:0010121 | arginine catabolic process to proline via ornithine |
| Process | GO:0006591 | ornithine metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.98 | 0.64 |
| Trophozoite | expressed | 3.61 | 0.03 |
| Schizont | expressed | 1.38 | 0.42 |
| Gametocyte | expressed | 2.25 | 0.17 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0608800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.978 | MFS: -2.496 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0107400)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0107400)
Modification: Disrupted | RMgm-4079
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q6LFH8
"Best" AlphaFill ligand hit: TAR (d(-)-tartaric acid, Local RMSD=0.03) with 5UC7 (Global RMSD=2.98)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.6.1.13 | ornithine aminotransferase | NH2OHserinepyruvateL-serineL-lysinespermineL-valineButyratevaleratecaproateL-leucineornithine... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P04181 | Ornithine aminotransferase, mitochondrial | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | CHEMBL220453GABACULINE |
Ortholog Group (OrthoMCL): OG6_100416
Most Similar Human Ortholog: P04181
TM-align score: 0.97 | RMSD: 1.31
Seq Identity: 0.55 | Length: 407 / 414
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000065154 | ornithine aminotransferase |
Protein Length: 414 | Molecular Weight (kDa): 46.055
UniProt ID(s): Q6LFH8
PDB ID(s): 3NTJ
Isoelectric Point: 6.85
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005814 | Aminotransferase class-III |
| InterPro | IPR010164 | Ornithine aminotransferase |
| InterPro | IPR015424 | Pyridoxal phosphate-dependent transferase |
| InterPro | IPR034758 | Ornithine aminotransferase, mitochondrial |
| PFam | PF00202 | Aminotransferase class-III |
| Superfamily | SSF53383 | Pyridoxal phosphate-dependent transferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 23 | 11 | 28 |
| disruptive | 2 | 5 | 8 | 12 |
| missense | 2 | 5 | 8 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 37 | 14 | 25 |
| disruptive | 3 | 18 | 16 | 31 |
| missense | 2 | 12 | 13 | 19 |
PlasmoDB Total SNPs: 98
Non-coding: 91 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8264733 | Characterization of a putative ornithine aminotransferase gene of Plasmodiumfalciparum. | Schmid SR, Linder P, Reese RT, Stanley HA | 10.1016/0166-6851(93)90076-a |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20673832 | Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase. | Jortzik E, Fritz-Wolf K, ..., Becker K | 10.1016/j.jmb.2010.07.039 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 26988354 | Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 inPlasmodium falciparum. | Hollin T, De Witte C, ..., Khalife J | 10.1186/s12864-016-2571-z |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |