PF3D7_0608900

Genome location: Pf3D7_06_v3:363,994..368,548(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.39	0.76
Schizont	expressed	0.35	0.78
Gametocyte	possibly expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0608900

Resistome Missense Mutations: L899F

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.01 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KST6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533691

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	31	15	48
disruptive	43	136	77	186
missense	25	128	69	167

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	65	36	62
disruptive	84	303	122	300
missense	50	248	105	215

PlasmoDB Total SNPs: 265

Non-coding: 173 | Synonymous: 61 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 995 | Molecular Weight (kDa): 120.667

UniProt ID(s): C6KST6

PDB ID(s): None

Isoelectric Point: 7.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A